Annual report pursuant to Section 13 and 15(d)

Note 2 - Summary of Significant Accounting Policies - Antidilutive Securities (Details)

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Note 2 - Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Employee Stock Option [Member]    
Stock options to purchase common stock (in shares) 4,014,475 2,694,224
Common Stock Warrants [Member]    
Stock options to purchase common stock (in shares) 642,622 642,622
Restricted Stock [Member]    
Stock options to purchase common stock (in shares) 57,500 10,000